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Publications

Peer-Reviewed Publications


STEP-UP
Drake JI, Bogaard HJ, Mizuno S, Clifton B, Xie B, Gao Y, Dumur CI, Fawcett P, Voelkel NF, Natarajan R. Molecular Signature of a Right Heart Failure Program in Chronic Severe Pulmonary  Hypertension. Am J Respir Cell Mol Biol. 2011 Dec;45(6):1239-47. doi: 10.1165/rcmb.2010-0412OC. Epub 2011 Jun 30. PubMed PMID: 21719795; PubMed Central PMCID: PMC3361357.

King AL, Gehr T, Cotterell A, Posner M, Mas V. MicroRNA profiles in allograft tissues and paired urines associate with chronic allograft dysfunction with IF/TA. Am J Transplant. 2011 Oct; 11(10):2110-22. doi: 10.1111/j.1600-6143.2011.03666.x.  Epub 2011 Jul 27. PubMed PMID: 21794090; PubMed Central PMCID: PMC3184368. 

Mas VR, Scian MJ, Archer KJ, Suh JL, David KG, Ren Q, Gehr TW, King AL, Posner MP, Mueller TF, Maluf DG. Pretransplant transcriptome profiles identify among kidneys with delayed graft function those with poorer quality and outcome. Mol Med. 2011 Sep 6. doi: 10.2119/molmed.2011.00159. Epub 2011 Sep 6. PubMed PMID: 21912807; PubMed Central PMCID: PMC3321827.

 

IMSD Undergraduate
Chiplunkar AR, Lung TK, Alhashem Y, Koppenhaver BA, Salloum FA, Kukreja RC, Haar JL, Lloyd JA. Krüppel-like factor 2 is required for normal mouse cardiac development. PLoS One. 2013;8(2):e54891. doi: 10. 137/journal.pone.0054891. Epub 2013 Feb 14. PubMed PMID: 23457456; PubMed Central PMCID: PMC3573061. 

Kim EY, Sturgill JL, Hait NC, Avni D, Valencia EC, Maceyka M, Lima S, Allegood J, Huang WC, Zhang S, Milstein S, Conrad D, Speigel S. Role of sphingosine kinase 1 and sphingosine-1-phosphate in CD40 signaling and IgE class switching. FASEB J. 2014 Oct;28(10:4347-58.PubMed PMID: 25002116; PubMed Central PMCID: 4202100. 

Fuller BF, Cortes DF, Landis MK, Yohannes H, Griffin HE, Stafflinger JE, Bowers MS, Lewis MH, Fox MA, Ottens AK.  Exposure of rats to environmental tobacco smoke during Cerebellar development alters behavior and perturbs mitochondrial energetics. Environ Health Perspect. 2012 Dec;120(12):1684-91. doi: 10. 1289/ehp. 1104857. Epub 2012 Sep 26. PubMed PMID: 23014793; PubMed Central PMCID: PMC3548280.

 

IMSD Graduate 
Wiebelhaus JM, Grim TW, Owens RA, Lazenka MF, Sim-Selley LJ, Abdullah RA, Niphakis MJ, Vann RE, Cravatt BF, Wiley JL, Negus SS, Lichtman AH. Delta-9 tetrahydrocannabinol (THC) and endocannobinoid degradadtive enzyme inhibitors attenuate intracranial self-stimulation (ICSS) in mice. J Pharmacol Exp Ther. 2015 Feb;352(2): 195-207. doi: 10. 1124/jpet. 114.218677. Epub 2014 Nov 14. PubMed PMID: 25398241 PubMed Central PMCID: PMC4293433.

Ramesh D, Ross GR, Schlosburg JE, Owens RA, Abdullah RA, Kinsey SG, Long JZ, Nomura DK, Sim-Selley LJ, Cravatt BF, Akbarali HI, Lichtman AH. Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated opioid withdrawal symptoms in mice. J Pharmacol Exp Ther. 2011 Oct;339(1):173-85. Epub 2011 Jun 30. PubMed PMID: 21719468; PubMed Central PMCID: PMC3186294.

Ngwainmbi J, De DD, Smith TH, El-Hage N, Fitting S, Kang M, Dewey WL, Hauser KF, Akbarali HI. Effects of HIV-1 Tat on enteric neuropathogenesis. J Neurosci. 2014 Oct22;34(43): 14243-51. doi. 10. 1523/JNEUROSCI.2283-14.2014. PubMed PMID: 25339738; PubMed Central PMCID: PMC4205550. 

Smith TH, Ngwainmbi J, Hashimoto A, Dewey WL, Akbarali HI. Morphine dependence in single enteric neurons from the mouse colon requires deletion of β-arrestin2. Physiol Rep. 2014 Sep4;2(9). pii: e12140. doi: 10. 14814/phy2.12140. Print 2014 Sep 1. PubMed PMID: 25194025; PMC4270231.

Smith TH, Ngwainmbi J, Grider JR, Dewey WL, Akbarali HI. An in-vitro preparation of isolated enteric neurons and glia from the myenteric plexus of the adult mouse. J. Vis Exp. 2013 aug 7;(78). doi: 10.3791/50688. PubMed PMID:23962959 PubMed Central PMCID: PMC3846983. 

 

IRACDA
Kabolizadeh P, Engelmann BJ, Pullen N, Stewart JK, Ryan JJ, Farrell NP. Platinum anticancer agents and antidepressants: desipramine enhances platinum-based cytotoxicity in human colon cancer cells.
J Biol Inorg Chem. 2011 Sep 15. [Epub ahead of print]

Quinn BA, Dash R, Azab B, Sarkar S, Das SK, Kumar S, Oyesanya RA, Dasgupta S, Dent P, Grant S, Rahmani M, Curiel DT, Dmitriev I, Hedvat M, Wei J, Wu B, Stebbins JL, Reed JC, Pellecchia M, Sarkar D, Fisher PB. Targeting Mcl-1 for the therapy of cancer. Expert Opin Investig Drugs. 2011 Oct;20(10):1397-411. Epub 2011 Aug 19.

Das SK, Bhutia SK, Kegelman TP, Peachy L, Oyesanya RA, Dasgupta S, Sokhi UK, Azab B, Dash R, Quinn BA, Kim K, Barral PM, Su ZZ, Boukerche H, Sarkar D, Fisher PB. MDA-9/syntenin: a positive gatekeeper of melanoma metastasis. Front Biosci. 2012 Jan 1;17:1-15.

Pullen NA, Falanga YT, Morales JK, Ryan JJ. The Fyn-STAT5 Pathway: A New Frontier in IgE- and IgG-Mediated Mast Cell Signaling. Front Immunol. 2012;3:117. Epub 2012 May 11.

Falanga YT, Chaimowitz NS, Charles N, Finkelman FD, Pullen NA, Barbour S, Dholaria K, Faber T, Kolawole M, Huang B, Odom S, Rivera J, Carlyon J, Conrad DH, Spiegel S, Oskeritzian CA, Ryan JJ. Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis.

J Immunol. 2012 May 1;188(9):4360-8. Epub 2012 Mar 26.

Pullen NA, Barnstein BO, Falanga YT, Wang Z, Suzuki R, Tamang TD, Khurana MC, Harry EA, Draber P, Bunting KD, Mizuno K, Wilson BS, Ryan JJ. Novel mechanism for Fc{epsilon}RI-mediated signal transducer and activator of transcription 5 (STAT5) tyrosine phosphorylation and the selective influence of STAT5B over mast cell cytokine production. J Biol Chem. 2012 Jan 13;287(3):2045-54. Epub 2011 Nov 30.

Golding SE, Pullen NA, Lama Tamang TD, Hubbard NM, Bulluck LP, Johnson AA, Smith-Mason J, Hill HH, and Barbour SE. "Undergraduate Research Training Blossoms at VCU: Pollinated by Students, Nurtured by Faculty."CUR Quarterly, Forthcoming: Fall 2012 vol.33.

Hedvat M, Emdad  L, Das SK, Kim K, Dasgupta S, Thomas S, Hu B, Zhu S, Dash R, Quinn BA, Oyesanya RA, Kegelamn TP, Sokhi UK, Sarkar S, Erdogan E, Menezes ME, Bhoopathi P, Wang XY, Pomper MG, Wei J, We B, Stebbins JL, 
Diaz PW, Reed JC, Pellecchia M, Sarkkar D, Fisher PB. Selected approaches for rational drug design and hgh throughput screening to identify anticancer molecules. Anticancer Agents Med Chem. 2012 Nov;12(9):1143-55. PubMed PMID22931411; PubMed Central PMCID: PMC3763986.

Garg K, Pullen NA, Oskeritzian CA, Ryan JJ, Bowlin GL. Macrophage funcitional polarization (M1/M2) in repsonse to varying fiber and pore dimensions of electrospun scaffolds. Biomaterials. 2013 Jun;34(18):4439-51. PubMed PMID: 23515178; PubMed Central PMCID: PMC3623371.

Fernando J, Faber TW, Pullen NA, Falanga YT, Kolawole EM, Oskertizian CA, Barnstein BO, Bandara G, Li G, Schwartz LB, spiegel S, Strauss DB, Conrad DH, Bunting KD, Ryan JJ. Genotype-dependent effect of TGF-β1 on mast cell function: targeting the Stat5 pathway. J Immunol. 2013 Nov;1:191(9):4505-13. PubMed PMID:24068671; PubMed Central PMCID: PMC3846427. 

Makhlynets O, Boal AK, Rhodes DV, Kitten T, Rosenzweig AC, Stubbe J. Streptococcus sanguinis class lb ribonucleotide reductase: high activity with both iron and manganese cofactors and structural insights. J Biol Chem. 2014 Feb;28;289(9):6259-72. PubMed PMID: 24381172; PubMed Central PMCID: PMC3937692.

Rhodes DV, Crump KE, Makhlynets O, Snyder M, Ge X, Xu P, Stubbe J, Kitten T. Genetic characterization and role in virulence of the ribonucleotide reductases of Streptococcus sanguinis. J Biol Chem. 2014 Feb;28;289(9):6273-87. PubMed PMID: 24381171; PubMed Central PMCID: PMC3937693. 

Morales JK, Saleem SJ, Martin RK, Saunders BL, Barnstein BO, Faber TW, Pullen NA, Kolawole EM, Brooks KB, Norton SK, Sturgill J, Graham L, Bear HD, Urban JF, Lantz CS, Conrad DH, Ryan JJ. Myeloid-derived supressor cells enhance IgE-mediated mast cell repsonses. J Leukoc Biol. 2014 Apr;95(4):643-50. PubMed PMID: 24338630; PubMed Central PMCID: PMC3958743.

Crump KE, Bainbridge B, Brusko S, Turner LS, Ge X, Stone V, Xu P, Kitten T. The relationship of the lipoprotein SisaB, manganese and superoxide dismutase in Steptococcus sanguinis virulence for endocarditis. Mol Microbiol. 2014 Jun;92(6):1243-59. PubMed PMID: 24750294; PubMed Central PMCID: PMC4070010. 

Martin RK, Saleem SJ, Folgosa L, Zellner HB, Damle Sr, Nguyen GK, Ryan JJ, Bear HD, Irani AM, Conrad DH. Mast cell histamine promotes the immunoregularity activity of myeloid-derived suppressor cells. J Leukoc Biol. 2014 Jul;96(1):151-9. PubMed PMID: 24610880; PubMed Central PMCID: PMC4056279.  

Faber TW, Pullen NA, Fernando JF, Kolawole EM, McLeod JJ, Taruselli M, Williams KL, Rivera KO, Barnstein BO, Conrad DH, Ryan JJ. ADAM10 is required for SCF-induced mast cell migration. Cell Immunol. 2014 Jul;290(1):80-8. PubMed PMID: 24950026; PubMed Central PMCID: PMC4128322. 

 

MARC
Mitchell C, Hamed HA, Cruickshanks N, Tang Y, Bareford MD, Hubbard N, Tye G, Yacoub A, Dai Y, Grant S, Dent P. Simultaneous exposure of transformed cells to SRC family inhibitors and CHK1 inhibitors causes cell death. Cancer Biol Ther. 2011 Aug 1;12(3):215-28. PubMed PMID: 21642769; PubMed Central PMCID: PMC3230482.

Bareford MD, Park MA, Yacoub A, Hamed HA, Tang Y, Cruickshanks N, Eulitt P, Hubbard N, Tye G, Burow ME,Fisher PB, Moran RG, Nephew KP, Grant S, Dent P. Sorafenib enhances pemetrexed cytotoxicity through an autophagy-dependent mechanism in cancer cells. Cancer Res. 2011 Jul 15;71(14):4955-67. PubMed PMID: 21622715; PubMed Central: PMC3139015.

Golding SE, Pullen NA, Lama Tamang TDHubbard NM, Bulluck LP, Johnson AA, Smith-Mason J, Hill HH, and Barbour SE. "Undergraduate Research Training Blossoms at VCU: Pollinated by Students, Nurtured by Faculty."CUR Quarterly, Forthcoming: Fall 2012 vol.33.

Pullen NA, Barnstein BO, Falanga YT, Wang Z, Suzuki R, Tamang TD, Khurana MC, Harry EA, Draber P, Bunting KD, Mizuno K, Wilson BS, Ryan JJ. Novel mechanism for Fc{epsilon}RI-mediated signal transducer and activator of transcription 5 (STAT5) tyrosine phosphorylation and the selective influence of STAT5B over mast cell cytokine production. J Biol Chem. 2012 Jan 13;287(3):2045-54. Epub 2011 Nov 30. PubMed PMID: 22130676; PubMed Central PMCID: PMC3265884.

 

PREP

Asomaning N, Archer KJ. High-throughput DNA methylation  datasets for evaluating false discovery rate methodologies. Comput Stat Data Anal. 2012 Jun 1;56(6):1748-56. PubMed PMID: 22611297; PubMed Central PMCID: PMC3352593.

Ramesh D, Ross GR, Schlosburg JE, Owens RA, Abdullah RA, Kinsey SG, Long JZ, Nomura DK, Sim-Selley LJ,Cravatt BF, Akbarali HI, Lichtman AH. Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated opioid withdrawal symptoms in mice. J Pharmacol Exp Ther. 2011 Oct;339(1):173-85. Epub 2011 Jun 30. PubMed PMID: 21719468; PubMed Central PMCID: PMC3186294.