IRACDA Publications 

Damle SR, Martin RK, Cockburn CL, Lownik JC, Carlyon JA, Smith AD, Conrad DH. ADAM10 and Notch1 on murine dendritic cells control the development of type 2 immunity and IgE production. Allergy. 2018 Jan;73(1):125-136. doi: 10.1111/all.13261. Epub 2017 Aug 31. PubMed PMID: 28745029; PubMed Central PMCID: PMC5739941.

Hyer MM, Phillips LL, Neigh GN. Sex Differences in Synaptic Plasticity: Hormones and Beyond. Front Mol Neurosci. 2018 Jul 31;11:266. doi: 10.3389/fnmol.2018.00266. eCollection 2018. PubMed PMID: 30108482; PubMed Central PMCID: PMC6079238.

Beyer AR, Rodino KG, VieBrock L, Green RS, Tegels BK, Oliver LD Jr, Marconi RT, Carlyon JA. Orientia tsutsugamushi Ank9 is a multifunctional effector that utilizes a novel GRIP-like Golgi localization domain for Golgi-to-endoplasmic reticulum trafficking and interacts with host COPB2. Cell Microbiol. 2017 Jul;19(7). doi: 10.1111/cmi.12727. Epub 2017 Feb 3. PubMed PMID: 28103630; PubMed Central PMCID: PMC5469707.

Damle SR, Martin RK, Cross JV, Conrad DH. Macrophage migration inhibitory factor deficiency enhances immune response to Nippostrongylus brasiliensis. Mucosal Immunol. 2017 Jan;10(1):205-214. doi: 10.1038/mi.2016.29. Epub 2016 Apr 6. PubMed PMID: 27049059; PubMed Central PMCID: PMC5053838.

Lownik JC, Luker AJ, Damle SR, Cooley LF, El Sayed R, Hutloff A, Pitzalis C, Martin RK, El Shikh MEM, Conrad DH. ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses. J Immunol. 2017 Oct 1;199(7):2305-2315. doi: 10.4049/jimmunol.1700833. Epub 2017 Aug 16. PubMed PMID: 28814605; PubMed Central PMCID: PMC5605448.

Nalli AD, Bhattacharya S, Wang H, Kendig DM, Grider JR, Murthy KS. Augmentation of cGMP/PKG pathway and colonic motility by hydrogen sulfide. AM J Physiol Gastrointest Liver Physiol. 2017 Oct 1;313(4):G330-G341. doi: 10.1152/ajpgi.00161.2017. Epub 2017 Jul 13. PubMed PMID: 28705807; PubMed Central PMCID: PMC5668569.

Ndaw VS, Abebayehu D, Spence AJ, Paez PA, Kolawole EM, Taruselli MT, Caslin HL, Chumanevich AP, Paranjape A, Baker B, Barnstein BO, Haque TT, Kiwanuka KN, Oskeritzian CA, Ryan JJ. TGF-β1 Suppresses IL-33-Induced Mast Cell Function. J Immunol. 2017 Aug 1;199(3):866-873. doi: 10.4049/jimmunol.1601983. Epub 2017 Jun 21. PubMed PMID: 28637902; PubMed Central PMCID: PMC5538185.

Rohrbach T, Maceyka M, Spiegel S. Sphingosine kinase and sphingosine-1-phosphate in liver pathobiology. Crit Rev Biochem Mol Biol. 2017 Oct;52(5):543-553. doi: 10.1080/10409238.2017.1337706. Epub 2017 Jun 15. PubMed PMID: 28618839; PubMed Central PMCID: PMC5944845.

Abebayehu D, Spence AJ, Qayum AA, Taruselli MT, McLeod JJ, Caslin HL, Chumanevich AP, Kolawole EM, Paranjape A, Baker B, Ndaw VS, Barnstein BO, Oskeritzian CA, Sell SA, Ryan JJ. Lactic Acid Suppresses IL-33-Mediated Mast Cell Inflammatory Responses via Hypoxia-Inducible Factor-1α-Dependent miR-155 Suppression. J Immunol. 2016 Oct 1;197(7):2909-17. doi: 10.4049/jimmunol.1600651. Epub 2016 Aug 24. PubMed PMID: 27559047; PubMed Central PMCID: PMC5026940.

Crump KE, Oakley JC, Xia-Juan X, Madu TC, Devaki S, Mooney EC, Sahingur SE. Interplay of Toll-Like Receptor 9, Myeloid Cells, and Deubiquitinase A20 in Periodontal Inflammation. Infect Immun. 2016 Dec 29;85(1). pii: e00814-16. doi: 10.1128/IAI.00814-16. Print 2017 Jan. PubMed PMID: 27849177; PubMed Central PMCID: PMC5203663.

Crump KE, Sahingur SE. Microbial Nucleic Acid Sensing in Oral and Systemic Diseases. J Dent Res.2016 Jan;95(1):17-25. doi: 10.1177/0022034515609062. Epub 2015 Oct 5. PubMed PMID: 26438211; PubMed Central PMCID: PMC4700663.

Kendig DM, Ets HK, Moreland RS. Effect of type II diabetes on male rat bladder contractility. Am J Physiol Renal Physiol. 2016 May 1;310(9):F909-22. doi: 10.1152/ajprenal.00511.2015. Epub 2016 Jan 28. PubMed PMID: 26823284; PubMed Central PMCID: PMC4867315.

Kendig DM, Hurst NR, Grider JR. Spatiotemporal Mapping of Motility in Ex Vivo Preparations of the Intestines. J Vis Exp. 2016 Jan 27;(107):e53263. doi: 10.3791/53263. PubMed PMID: 26863156; PubMed Central PMCID: PMC4781693.

Oki AT, Huang B, Beyer AR, May LJ, Truchan HK, Walker NJ, Galloway NL, Borjesson DL, Carlyon JA. Anaplasma phagocytophilum APH0032 Is Exposed on the Cytosolic Face of the Pathogen-Occupied Vacuole and Co-opts Host Cell SUMOylation.Front Cell Infect Microbiol. 2016 Sep 22;6:108. doi: 10.3389/fcimb.2016.00108. eCollection 2016. PubMed PMID: 27713867; PubMed Central PMCID: PMC5031783.

Paranjape A, Chernushevich O, Qayum AA, Spence AJ, Taruselli MT, Abebayehu D, Barnstein BO, McLeod JJ, Baker B, Bajaj GS, Chumanevich AP, Oskeritzian CA, Ryan JJ. Dexamethasone rapidly suppresses IL-33-stimulated mast cell function by blocking transcription factor activity. J Leukoc Biol. 2016 Dec;100(6):1395-1404. doi: 10.1189/jlb.3A0316-125R. Epub 2016 Jul 21. PubMed PMID: 27443878; PubMed Central PMCID: PMC5109997.

Qayum AA, Paranjape A, Abebayehu D, Kolawole EM, Haque TT, McLeod JJ, Spence AJ, Caslin HL, Taruselli MT, Chumanevich AP, Baker B, Oskeritzian CA, Ryan JJ. IL-10-Induced miR-155 Targets SOCS1 To Enhance IgE-Mediated Mast Cell Function. J Immunol. 2016 Jun 1;196(11):4457-67. doi: 10.4049/jimmunol.1502240. Epub 2016 Apr 29. PubMed PMID: 21783599; PubMed Central PMCID: PMC4875869.

Beyer AR, VieBrock L, Rodino KG, Miller DP, Tegels BK, Marconi RT, Carlyon JA. Orientia tsutsugamushi Strain Ikeda Ankyrin Repeat-Containing Proteins Recruit SCF1 Ubiquitin Ligase Machinery via Poxvirus-Like F-Box Motifs. J Bacteriol. 2015 Oct;197(19):3097-109. doi: 10.1128/JB.00276-15. Epub 2015 Jul 13. PubMed PMID: 26170417; PubMed Central PMCID: PMC4560276.

Kendig DM, Grider JR. Serotonin and colonic motility. Neurogastroenterol Motil. 2015 Jul;27(7):899-905. doi: 10.1111/nmo.12617. PubMed PMID: 26095115; PubMed Central PMCID: PMC4477275.

McLeod JJ, Baker B, Ryan JJ. Mast cell production and response to IL-4 and IL-13. Cytokine. 2015 Sep;75(1):57-61. doi: 10.1016/j.cyto.2015.05.019. Epub 2015 Jun 15. PubMed PMID: 26088754; PubMed Central PMCID: PMC4532630.

Wahl SE, Kennedy AE, Wyatt BH, Moore AD, Pridgen DE, Cherry AM, Mavila CB, Dickinson AJ. The role of folate metabolism in orofacial development and clefting. Dev Biol. 2015 Sep 1;405(1):108-22. doi: 10.1016/j.ydbio.2015.07.001. Epub 2015 Jul 2. PubMed PMID: 26144049; PubMed Central PMCID: PMC4546841.

Crump KE, Bainbridge B, Brusko S, Turner LS, Ge X, Stone V, Xu P, Kitten T. The relationship of the lipoprotein SisaB, manganese and superoxide dismutase in Steptococcus sanguinis virulence for endocarditis. Mol Microbiol. 2014 Jun;92(6):1243-59. doi: 10.1111/mmi.12625. Epub 2014 May 12. PubMed PMID: 24750294; PubMed Central PMCID: PMC4070010.

Faber TW, Pullen NA, Fernando JF, Kolawole EM, McLeod JJ, Taruselli M, Williams KL, Rivera KO, Barnstein BO, Conrad DH, Ryan JJ. ADAM10 is required for SCF-induced mast cell migration. Cell Immunol. 2014 Jul;290(1):80-8. doi: 10.1016/j.cellimm.2014.05.005. Epub 2014 May 21. PubMed PMID: 24950026; PubMed Central PMCID: PMC4128322. 

Martin RK, Saleem SJ, Folgosa L, Zellner HB, Damle Sr, Nguyen GK, Ryan JJ, Bear HD, Irani AM, Conrad DH. Mast cell histamine promotes the immunoregularity activity of myeloid-derived suppressor cells. J Leukoc Biol. 2014 Jul;96(1):151-9. doi: 10.1189/jlb.5A1213-644R. Epub 2014 Mar 7. PubMed PMID: 24610880; PubMed Central PMCID: PMC4056279.  

Morales JK, Saleem SJ, Martin RK, Saunders BL, Barnstein BO, Faber TW, Pullen NA, Kolawole EM, Brooks KB, Norton SK, Sturgill J, Graham L, Bear HD, Urban JF, Lantz CS, Conrad DH, Ryan JJ. Myeloid-derived supressor cells enhance IgE-mediated mast cell repsonses. J Leukoc Biol. 2014 Apr;95(4):643-50. doi: 10.1189/jlb.0913510. Epub 2013 Dec 12. PubMed PMID: 24338630; PubMed Central PMCID: PMC3958743.

Rhodes DV, Crump KE, Makhlynets O, Snyder M, Ge X, Xu P, Stubbe J, Kitten T. Genetic characterization and role in virulence of the ribonucleotide reductases of Streptococcus sanguinis. J Biol Chem. 2014 Feb 28;289(9):6273-87. doi: 10.1074/jbc.M113.533620. Epub 2013 Dec 31. PubMed PMID: 24381171; PubMed Central PMCID: PMC3937693. 

Fernando J, Faber TW, Pullen NA, Falanga YT, Kolawole EM, Oskertizian CA, Barnstein BO, Bandara G, Li G, Schwartz LB, spiegel S, Strauss DB, Conrad DH, Bunting KD, Ryan JJ. Genotype-dependent effect of TGF-β1 on mast cell function: targeting the Stat5 pathway. J Immunol. 2013 Nov 1;191(9):4505-13. doi: 10.4049/jimmunol.1202723. Epub 2013 Sep 25. PubMed PMID:24068671; PubMed Central PMCID: PMC3846427. 

Garg K, Pullen NA, Oskeritzian CA, Ryan JJ, Bowlin GL. Macrophage funcitional polarization (M1/M2) in repsonse to varying fiber and pore dimensions of electrospun scaffolds. Biomaterials. 2013 Jun;34(18):4439-51. doi: 10.1016/j.biomaterials.2013.02.065. Epub 2013 Mar 17. PubMed PMID: 23515178; PubMed Central PMCID: PMC3623371.

Makhlynets O, Boal AK, Rhodes DV, Kitten T, Rosenzweig AC, Stubbe J. Streptococcus sanguinis class lb ribonucleotide reductase: high activity with both iron and manganese cofactors and structural insights. J Biol Chem. 2014 Feb 28;289(9):6259-72. doi: 10.1074/jbc.M113.533554. Epub 2013 Dec 31. PubMed PMID: 24381172; PubMed Central PMCID: PMC3937692.

Das SK, Bhutia SK, Kegelman TP, Peachy L, Oyesanya RA, Dasgupta S, Sokhi UK, Azab B, Dash R, Quinn BA, Kim K, Barral PM, Su ZZ, Boukerche H, Sarkar D, Fisher PB. MDA-9/syntenin: a positive gatekeeper of melanoma metastasis. Front Biosci (Landmark Ed). 2012 Jan 1;17:1-15. PubMed PMID: 22201728.

Falanga YT, Chaimowitz NS, Charles N, Finkelman FD, Pullen NA, Barbour S, Dholaria K, Faber T, Kolawole M, Huang B, Odom S, Rivera J, Carlyon J, Conrad DH, Spiegel S, Oskeritzian CA, Ryan JJ. Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis.J Immunol. 2012 May 1;188(9):4360-8. doi: 10.4049/jimmunol.1003223. Epub 2012 Mar 26. PubMed PMID: 22450804; PubMed Central PMCID: PMC3536057.

Golding SE, Pullen NA, Lama Tamang TD, Hubbard NM, Bulluck LP, Johnson AA, Smith-Mason J, Hill HH, and Barbour SE. "Undergraduate Research Training Blossoms at VCU: Pollinated by Students, Nurtured by Faculty."CUR Quarterly, Forthcoming: Fall 2012 vol.33.

Hedvat M, Emdad  L, Das SK, Kim K, Dasgupta S, Thomas S, Hu B, Zhu S, Dash R, Quinn BA, Oyesanya RA, Kegelamn TP, Sokhi UK, Sarkar S, Erdogan E, Menezes ME, Bhoopathi P, Wang XY, Pomper MG, Wei J, We B, Stebbins JL, Diaz PW, Reed JC, Pellecchia M, Sarkkar D, Fisher PB. Selected approaches for rational drug design and hgh throughput screening to identify anticancer molecules. Anticancer Agents Med Chem. 2012 Nov;12(9):1143-55. PubMed PMID: 22931411; PubMed Central PMCID: PMC3763986.

Pullen NA, Barnstein BO, Falanga YT, Wang Z, Suzuki R, Tamang TD, Khurana MC, Harry EA, Draber P, Bunting KD, Mizuno K, Wilson BS, Ryan JJ. Novel mechanism for Fc{epsilon}RI-mediated signal transducer and activator of transcription 5 (STAT5) tyrosine phosphorylation and the selective influence of STAT5B over mast cell cytokine production. J Biol Chem. 2012 Jan 13;287(3):2045-54. doi: 10.1074/jbc.M111.311142. Epub 2011 Nov 30. PubMed PMID: 22130676; PubMed Central PMCID: PMC3265884.

Pullen NA, Falanga YT, Morales JK, Ryan JJ. The Fyn-STAT5 Pathway: A New Frontier in IgE- and IgG-Mediated Mast Cell Signaling. Front Immunol. 2012 May 11;3:117. doi: 10.3389/fimmu.2012.00117. eCollection 2012. PubMed PMID: 22593761; PubMed Central PMCID: PMC3350083.

Kabolizadeh P, Engelmann BJ, Pullen N, Stewart JK, Ryan JJ, Farrell NP. Platinum anticancer agents and antidepressants: desipramine enhances platinum-based cytotoxicity in human colon cancer cells.J Biol Inorg Chem. 2012 Jan;17(1):123-32. doi: 10.1007/s00775-011-0836-1. Epub 2011 Sep 15. PubMed PMID: 21918844; PubMed Central PMCID: PMC3250067.

Quinn BA, Dash R, Azab B, Sarkar S, Das SK, Kumar S, Oyesanya RA, Dasgupta S, Dent P, Grant S, Rahmani M, Curiel DT, Dmitriev I, Hedvat M, Wei J, Wu B, Stebbins JL, Reed JC, Pellecchia M, Sarkar D, Fisher PB. Targeting Mcl-1 for the therapy of cancer. Expert Opin Investig Drugs. Expert Opin Investig Drugs. 2011 Oct;20(10):1397-411. doi: 10.1517/13543784.2011.609167. Epub 2011 Aug 19. PubMed PMID: 21851287; PubMed Central PMCID: PMC3205956.